The book maps the reflection of social and health threats of substance abuse in the population of the Czech Republic. The dependence of the perception of substance abuse on age, gender, and education is analyzed. The book also offers an analysis of the relationship of these threats to the value preferences of substance users, including the use of this value context in prevention and intervention in social work and social pedagogy. Attention is given to four key groups of addictive substances: alcohol, tobacco and tobacco products, drugs and medicines, and illicit drugs.